Inside of the Mercury spacecraft in which astronaut John H. Glenn Jr. became the first American to orbit the Earth. On February 20, 1962, Glenn circled the Earth three times. The space flight lasted 4 hours and 55 minutes. "Friendship 7" landed in the Atlantic Ocean.
Full information on the mission

First American to Orbit Earth - John Glenn

Gemini 4 (GT-4) was launched aboard a Titan II rocket on June 3, 1965 carrying astronauts James McDivitt and Ed White into earth orbit. The flight lasted 4 days and included an historic space walk by Ed White, the first by an American. White’s 22 minute "extravehicular activity" (EVA) was broadcast live, demonstrating astronauts' ability to maneuver in space. The flight also included a rendezvous maneuver with the second stage of the Titan II rocket. The maneuver was aborted after pilot Jim McDivitt experienced unexpected difficulties guiding the spacecraft. Other experiments during this flight included earth photography, space radiation measurements, and medical effects of prolonged weightlessness.
First American Space Walk - Ed White

The Space Shuttle Endeavour lights up the night sky as it embarks on the first U.S. mission dedicated to the assembly of the International Space Station.
Space Shuttle Endeavour Lauchs to start assembly of ISS